Imaging of adrenocortical metastases with [11C]metomidate
Markus Mitterhauser1, 2, Georg Dobrozemsky3, Georg Zettinig1, Wolfgang Wadsak1, Heinrich Vierhapper4, Robert Dudczak1, Kurt Kletter1
1 Department of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
2 Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna Vienna, Austria
3 Department of Nuclear Medicine, Medical University of Innsbruck Innsbruck, Austria
4 Department of Internal Medicine, Medical University of Vienna Vienna, Austria
Received: 18 January 2006 / Accepted: 12 February 2006 / Published online: 24 May 2006 @ Springer-Verlag 2006
Eur J Nucl Med Mol Imaging (2006) 33:974 DOI 10.1007/s00259-006-0103-9
As reported previously, the 11ß-hydroxylase inhibitor [ C]metomidate, as well as [18F]FDG, may be used for imaging of adrenal masses [1-4]. The positron emission tomography images presented here were acquired in a 50- year-old patient with metastatic adrenocortical carcinoma. Only some of the known metastases show [18F]FDG uptake (right: image obtained 40 min after administration of 370 MBq [18F]FDG), whereas intense accumulation of [11C]metomidate is seen (left: image obtained 20 min after administration of 300 MBq [ C]metomidate).
Markus Mitterhauser ☒
X Department of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria e-mail: markus.mitterhauser@meduniwien.ac.at Tel .: +43-1-404001557; Fax: +43-1-404001559
Lung metastases
Peritoneal metastasis
Stomach
Gall bladder Right adrenal gland
Local recurrence
References
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3. Mitterhauser M, Dobrozemski G, Wadsak W, Zettinig G, Viernstein H, Zolle I, et al. [11C]MTO may be superior to [18F] FDG for PET imaging of metastases from adrenocortical origin [abstract]. Eur J Nucl Med Mol Imaging 2002; 29(Suppl 1): S372
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