Supplementary Table 1
Radiomic Texture Features calculated with LifeX
(C Nioche, F Orlhac, S Boughdad, S Reuze, J Goya-Outi, C Robert, C Pellot-Barakat, M Soussan, F Frouin, and I Buvat. LIFEx: a freeware for radiomic feature calculation in multimodality imaging to accelerate advances in the characterization of tumor heterogeneity. Cancer Research 2018; 78(16):4786-4789)
| Intensity_based_P25 | P25 corresponds more or less to the first quartile (Q1). It is defined as the middle number between the smallest number and the median of the data set |
| Intensity_based_P75 | The 75th percentile corresponds to the third quartile (Q3). It is the middle value between the median and the highest value of the data set |
| Intensity_based_TLG | is the Total Lesion Glycolysis defined as the product of SUVmean by Volume in mL |
| Intensity - based_RIM | is the Radial Intensity Mean "Intensity_based_RIM_mean" of successive layers of voxels (envelope) from the outside of the region to the inside. Each layer is 1 voxel thick. These envelopes are getting smaller and smaller (3D erosion of 1 voxel) up to the center of the ROI |
| Intensity_histogram_AUC_CSH | quantitative index of tracer uptake heterogeneity and/or heterogeneous response where lower values correspond with increased heterogeneity. |
| Grey level co-occurrence matrix (GLCM) | takes into account the arrangements of pairs of voxels to calculate textural indices. The GLCM is calculated from 13 different directions in 3D with a 8-voxel distance (II -- > dll) relationship between neighboured voxels. The index value is the average of the index over the 13 directions in space (X, Y, Z) |
| Neighborhood grey-level difference matrix (NGLDM) | Corresponds to the difference of grey-levels between one voxel and its 26 neighbors in 3 dimensions (8 in 2D). Three texture indices can be computed from this matrix |
| Grey-level run length matrix (GLRLM) | gives the size of homogeneous runs for each grey level. This matrix is computed for the 13 different directions in 3D (4 in 2D) and for each of the 11 texture indices derived from this matrix, the 3D value is the average over the 13 directions in 3D (4 in 2D). The element (i, j) of GLRLM corresponds to the number of homogeneous runs of j voxels with intensity i in an image and is called GLRLM(i, j) thereafter |
| Grey-level zone length matrix (GLZLM) | provides information on the size of homogeneous zones for each grey-level in 3 dimensions (or 2D). It is also named Grey Level Size Zone Matrix (GLSZM). From this matrix, 11 texture indices are computed. Element (i, j) of GLZLM corresponds to the number of homogeneous zones of j voxels with the intensity i in an image and is called GLZLM(i, j) thereafter |
| compacity | The compacity feature reflects how compact the Volume of Interest is. Compacity = A3/2 /V where V and A correspond to the volume and the surface of the Volume Of Interest based on the Delaunay triangulation. |
| Volume | is the volume in mesh of ROI |
| VoxelsCounting | is not IBSI compliant. It is the number of voxels in the ROI |
| ApproximateVolume | is the number of voxels multiplied by the volume of a voxel |
| MaxValueCoordinates | is pretty self explanatory. It indicates the coordinates of the maximum value |
| CenterOfMass (COMCoor) | is the center of mass coordinates of the studied ROI in voxels |
| WeightedCenterOfMass (WCOMCoor) | is the weighted intensity center of mass coordinates of the studied ROI in voxels |
| HOCMax | is the distance in millimeter between the activity Hotspot with maxValue |
| HOC05mLPeak | is the distance in millimeter between the activity Hotspot with 0.5 mL peakValue |
| HOC1mLPeak | is the distance in millimeter between the activity Hotspot with 1 mL peakValue |
| NormalizedHOCradiusROI | is the distance in millimeter between the normalized ROI maximum radius of the activity hotspot with maxValue |
| NormalizedHOCradiusSphere | is the distance in millimeter between the normalized sphere radius of the activity hotspot with maxValue |
| NormalizedCenterOfMassShiftMaxRad iusROI | is the distance in millimeter between the normalized ROI maximum radius activity with weighted center of mass |
| NormalizedCenterOfMassShiftRadiusS phere | is the distance in millimeter between the normalized sphere radius of the activity hotspot with weighted center of mass |
| MaxValuePerimeter2DDistance | is the closest 2D distance between maxValue voxel to the segmented tumor border |
| MaxValuePerimeter3DDistance | is the closest 3D distance between maxValue voxel to the segmented tumor border |
| Peak05mLPerimeter2DDistance | is the closest 2D distance between Peak0.5mL voxel to the segmented tumor border |
| Peak05mLPerimeter3DDistance | is the closest 3D distance between Peak0.5mL voxel to the segmented tumor border |
| Peak1mLPerimeter2DDistance | is the closest 2D distance between Peak1mL voxel to the segmented tumor border |
| Peak1mLPerimeter3DDistance | is the closest 3D distance between Peak1mL voxel to the segmented tumor border |
| MaxValueNormalizedWithRadiusSpher ePerimeter2DDistance | is the closest 2D distance between maxValue voxel to the segmented tumor border divided by the mean spherical radius |
| MaxValueNormalizedWithRadiusSpher ePerimeter3DDistance | is the closest 3D distance between maxValue voxel to the segmented tumor border divided by the mean spherical radius |
| Peak05mLNormalizedWithRadiusSphe rePerimeter2DDistance | is the closest 2D distance between Peak0.5mL voxel to the segmented tumor border divided by the mean spherical radius |
| Peak05mLNormalizedWithRadiusSphe rePerimeter3DDistance | is the closest 3D distance between Peak0.5mL voxel to the segmented tumor border divided by the mean spherical radius |
| Peak1mLNormalizedWithRadiusSpher ePerimeter2DDistance | is the closest 2D distance between Peak1mL voxel to the segmented tumor border divided by the mean spherical radius |
| Peak1mLNormalizedWithRadiusSpher ePerimeter3DDistance | is the closest 3D distance between Peak1mL voxel to the segmented tumor border divided by the mean spherical radius |
| MaxValueNormalizedWithRadiusRoiPe rimeter2DDistance | s the closest 2D distance between maxValue voxel to the segmented tumor border divided by the mean roi radius |
| MaxValueNormalizedWithRadiusRoiPe rimeter3DDistance | is the closest 3D distance between maxValue voxel to the segmented tumor border divided by the mean roi radius |
| Peak05mLNormalizedWithRadiusRoiP erimeter2DDistance | is the closest 2D distance between Peak0.5mL voxel to the segmented tumor border divided by the mean roi radius |
| Peak05mLNormalizedWithRadiusRoiP erimeter3DDistance | is the closest 3D distance between Peak0.5mL voxel to the segmented tumor border divided by the mean roi radius |
| Peak1mLNormalizedWithRadiusRoiPer imeter2DDistance | is the closest 2D distance between Peak1mL voxel to the segmented tumor border divided by the mean roi radius |
| Peak1mLNormalizedWithRadiusRoiPer imeter3DDistance | is the closest 3D distance between Peak1mL voxel to the segmented tumor border divided by the mean roi radius |
| SphereDiameter | is the diameter of sphere equal to equivalent volume (in mm) |
| StandardDeviation | is the standard deviation of all voxels intensity |
| IntensityPeakDiscretizedVolumeSough t(0.5mL) | See its equivalent of 1mL |
| GlobalIntensityPeak(0.5mL) | See its counterpart of 1mL |
| IntensityPeakDiscretizedVolumeSough t(1mL) | is the peak intensity of volume 1mL, based on discretized values |
| GlobalIntensityPeak(1mL) | corresponds to IBSI_0F91 |
| LocalIntensityPeak | corresponds to IBSI_VJGA |