38451783

Supplementary Figure S1

A

100

CUACC1

CUACC2

Cell Viability (%)

80

H295R

60

SW13

40

20

0

1

10

100

1000

Bortezomib (nM)

Cell line	CUACC1	CUACC2	H295R	SW13
IC50 (nM)	35.0	3.2	7.3	3.6

B

SW13

r = - 0.98

8.0

p = 0.018

TAK-243 (IC50 [-log10])

7.6

ACC2

ACC1

7.2

H295R

0

2

4

6

ABCB1 (RNA-seq [-log2])

Supplementary Figure S1. A. Concentration-response curves and IC50 values for Bortezomib in ACC cell lines and SW-13. B. Activity of TAK-243 is negatively correlated with MDR1 (encoded by ABCB1) expression (left) and ACC cell lines have low SLFN11 expression (right) measured by RNA-seq.

r = 0.8

SW13

p = 0.2

ACC2

ACC1

H295R

0

1

2

3

4

SLFN11 (RNA-seq [-log2])