First-in-human evaluation of [18F]CETO; a novel tracer for adrenocortical tumours
Online Resource 3
Isabella Silins1, Anders Sundin1, Mark Lubberink1, Lleah O’Sullivan1, Mark Gurnell4, Franklin Aigbirhio6, Morris Brown5, Anders Wall1, Tobias Åkerström1, Sara Roslin2, Per Hellman1 *, Gunnar Antoni2*
Departments of 1 Surgical Sciences, 2 Medicinal Chemistry and 3 Medical Sciences at Uppsala University, 4 Institute of Metabolic Science & Department of Medicine, University of Cambridge, 5William Harvey Heart Centre, Queen Mary University of London and 6Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge.
*Contributed equally as last author
First/corresponding author: Isabella Silins, Phd-student Uppsala University isabella.silins@surgsci.uu.se
+4673 680 73 93
ORCID ID 0000-0003-3802-0974
PET images overlaid on CT images. For delineation of VOIS with obvious and high PET-uptake, the color (Sokoloff) scale was set so that the peak level of the structure was presented as white, whereupon the delineations were done at the yellow border of the uptake. VOIager 4.0.7 (GE Healthcare, Uppsala, Sweden) was used for delineation of healthy organs/tissues. Hermes Hybrid Viewer (Hermes Medical Solutions AB, Stockholm, Sweden) ) was used for delineation of aorta and adrenals.
| Region Example of region name | Slices | Standardized method for delineation |
|---|---|---|
| Adrenal sinister/dexter | x ☒ | The whole adrenal, was delineated all image plans. R = right adrenal, L = left adrenal For patient 11, lacking right adrenal due to ACC, the VOI for the ACC metastasis is marked T. |
| Patient 3. Left adrenal: cortisol producing adenoma | L 2L 6 R3R6 | |
| Right adrenal: Normal. | ||
| Patient 4: Left adrenal: Normal Right adrenal: Conn adenoma | n 13/R 12 L 2/L 13 TR 3R 13 |
Patient 11: Left adrenal: Normal Right adrenal: X Tumor = ACC metastasis
(Red circular VOI: aorta)
3 T 6
1/ 9
2/L 13
Patient 15: Right adrenal: Non func. Adenomas. Left adrenal: Non func. Adenoma.
R 3/R 3
+2/L 11
Aorta (whole blood) Aorta_dyn_001
5 consec. Slices PET/CT
The VOIs were delineated in Aorta-Descendens, in 5 consecutive slices, covering 4 central pixels
Anatomical landmark: first slice was located five image slices below the level where the bronchi enter the lung. Delineated in five consecutive slices downwards.
| Spleen spleen_dyn_001 | 3 consecutive and central image plans | |
|---|---|---|
| 5+0 | ||
| Pancreas Pancreas_dyn_003 | Representative image at upper-mid-low level, Do not mix up with duodenum, (duodenum is located approx. on the kidney level and passes just frontal to aorta ... Check CT image as well to see the structure, central in image plan and banana-shaped S 3/16 | |
| Vertebra Vertebra_001_dyn If possible, 3 slices central in the vertebral body (Muscle VOI is visible in lower left quadrant) | 3 consec. vertebrae PET/CT | Anatomical landmark: One spinal vertebra at the levels of kidney |
| DEOV 49,9cm VPEX 8 Randoms : Singles | aug 23 2019 10:54:20 fm ME : 3,4 L | |||
| Liver Liver_dyn_001 | 1 repr. Slice PET/CT | One circular VOI in 3 slices, dorsal lobe (small partial volume effects) A93 003 003 C D 0 + D 0 | enough to avoid | |
| Kidney_cortex_sin Kideny_ctx_dyn_001_sin | 3 repr. Slice PET/CT | 3 central slices 00 3 slices lateral of spinal column | ||
| Muscle | ||||
| Muscle_dyn_001 | ||
|---|---|---|
| 3 slices below sin kidney, if not possible to mark in area above the left kidney. 0 0 + D O 3 slices as a cortical roi of the stomach wall | ||
| Fat Vicsc_fat_dyn_001 | ||
| Stomach Wall Stomach_wall_dyn_001 | ||
| 4 0 |
| Intestine | ☒ | ||
|---|---|---|---|
| Intestine_dyn_001 | |||