MEDICAL SCIENCE MONITOR
| Received: | 2022.07.11 |
| Accepted: | 2022.07.11 |
| Available online: | 2022.07.18 |
| Published: | 2022.07.28 |
ERRATUM
Errate: Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis
Zhengqing Yang Hui Cheng Yazhou Zhang Yan Zhou
Department of Urology, Shanghai Yangsi Hospital, Shanghai, PR China
Corresponding Author: Yan Zhou, e-mail: zhou.yanys@hotmail.com
The authors would like to correct the following errors:
The original published paper had the wrong labels for Figure 3F. Figure 3 should have been as follows:
A
Sample denrogram and trait heatmap
B
Scale independence
D
7 8 91011121914151817161820
1.1
80
Scale free topology model fit, signed R2
0.8
3
0.9
75
0.6
Height
GSN1972939
GSM197221
GSM1972924
GSM1972333
0.7
2
70
0.4
0.5-
MEnanejow hibe1
GSM11900927
GSM11972931
GSM1972985
0.2
MEbrovin?
MEbrovin4
MEdarkgre
MEgreen
MEmagenta
65
MEdarlorange
MEdarkturquoise
MEblad
MEplum3
MElightcyan
MElightsteelblue1
ME avenderblush
MEoran gerede
MEantiqu en hite4
MEbluez
GSM1972937
60
1
GSM1972926
GSM1972928
GSM1972944
GSM1972919
GSM1972929
GSM1972938
GSM1972942
5
10
15
20
55
GSM1972920
GSM1972922
Soft threshold (power) Scale independence
1.0
50
45
3000
1
0.8
GSM1972925
GSM1972923
GSM1972940
GSM1972934
GSM1972930
GSM1972947
Mean connectivity
2000
0.6
0.4
OS time
1000
2
0.2
500
3
0
0.0
5 6 7 8 9 1011121314151617181820
5
10
15
20
Soft threshold (power)
C
Cluster dendogram
Network heatmap plot, selected genes
E
1.00-
0.95
0.90-
Height
0.85
0.80
0.75
0.70-
0.65
Dynamic tree cut
Merged dynamic
6
F
G
H
GEO-COX
GEO-DEGS
774
255
144
MEnavajowhite1
MEbrown2
(63)
· Down Stable
-0.29
5
MEbrown4
-0.17
1.0
(0.4)
Up
25
6
MEdarkorange
0.27
MEdarkturquise
(0.2)
MEdarkgrey
0.067 (0.8)
0.2
0.5
4
302
MEblack
(0.4)
0.44
MEplum3
(0.02)
0.36
-log10 (p-value)
MElightcyan1
(0.03)
0.13 (0.6)
WGCNA-plum3
MElightsteelblue1
0.34 (0.1)
0.0
MEgreen
-0.29 (0.2)
2
Size of each list
MEmagenta
1059
-0.26
529.5
1095
MElavenderblush2
(0.2)
0.076
410
MEorangered4
(0.7)
-0.5
0
338
-0.28
TCGA-DEXs WGCNA-skyblue2
MEantiquawhite4
(0.2)
TCGA-COX
-0.47
MEblue2
(0.02)
0
Number of lements: specific (1) or shared by 2,3, . lists
-0.68
286
1220
(3e-04)
OS time
-1.0
-2
-1
0
1
2
3 (5) 2
1
log2 (fold change)
A
TCGA-ACC cohort
B
GSE76021 dataset
NDRG4 level +High+Low
CKS2 level
+
High+Low
NDRG4 level + High+Low
CKS2 level
+High+Low
1.00-
1.00
1.00-
1.00
Survival probability
0.75
Survival probability
0.75
Survival probability
0.75
Survival probability
0.75
0.50
0.50
0.50
0.50
0.25
p<0.001
0.25
p<0.001
0.25
p=0.002
0.25
p<0.001
0.00
0.00
0.00
0.00
0 1 2 3 4 5 6 7 8 9101112 Time (years)
0
1 2 3
4 1 5
6 7
8
9 1011 12
0 1 2 34 56 7 8 9 101112131415 16
0 12 3 4 5 6 7 8 9 101112 131415 16 Time (years)
Time (years)
Time (years)
C
Disease-free survival
D
Mitotane therapy
NDRG4 +High+Low
CKS2 +High+Low
NDRG4
+1 High+Low
CKS2
+
High-Low
1.00-
1.00
1.00-
1.00-
Survival probability
0.75
Survival probability
0.75
Survival probability
0.75
Survival probability
0.75
0.50
0.50
0.50
0.50
0.25
p<0.001
0.25
p<0.001
0.25
p<0.001
0.25
p<0.001
0.00
0.00
0.00
0.00
0
2
3
4
15678
9101112
0
1
2
3
4 5 6 7 8 9 101112
0 1 2 3 4 5 6 7 8 9101112 Time (years)
0
Time (years)
2 3 4 5 6 7 8 9 101112 Time (years)
Time (years)
E
F
3-year survival
5-year survival
100
100
80
80
Sensivity
60
Sensivity
60
40
40
AUC
20
AUC
P value
P value
Stage
0.804
reference
20
Stage
0.891
reference
CKS2
0.882
0.2091
CKS2
0.9763
NDRG4
0.906
0.1182
NDRG4
0.892
0.866
0.6718
0
Risk score
0.974
0.0016
0
Risk score
0.969
0.0313
0
20
40
60
80
100
0
20
40
60
80
100
100-specificity
100-specificity
ERRATUM
The formula on page 4 should read:
Riskscore=e^(B.+B +B *expression *expression )/(1+ e^(B.+B +B *expression +B )
TPstage(n) “PNDRG4
NDRG4 PCKS2
CKS2
tage(n) “PNDRG4
NDRG4 TPCKS2 * *expression CKS2
B represented regression coefficients. Expression represented the level of gene expression.
Reference:
Zhengqing Yang, Hui Cheng, Yazhou Zhang, Yan Zhou: Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis. Med Sci Monit, 2021; 27: e928523. DOI: 10.12659/MSM.928523
Full-text PDF:
https://www.medscimonit.com/abstract/index/idArt/937786
This work is licensed under Creative Common Attribution- NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) e937786-3