31998416

Supplemental Figure 1. CD276-related signatures in ACC. (A) Gene set enrichment analysis (GSEA) of genes that strongly coexpressed with CD276. The representative gene sets are "immune system", "adaptive immune system", "innate immune system" and "cytokine signaling in immune system". (B) Heat map of genes from the GSEA "immune system" gene set. The median expression value was used as a cut-off of high expression (red) and low expression (green) of genes. (C) CD276-related functional pathways enriched in ACC. The Q value is shown as dots with different colors. The number of enrichment genes is shown as dots with different sizes. The ratio of the coexpressed gene number and the number of annotated genes in each pathway was calculated as the rich factor.

A

B

Enrichment plot: REACTOME_IMMUNE_SYSTEM

Enrichment plot: REACTOME_ADAPTIVE_IMMUNE_SYSTEM

-

CD276

&

CD276

0

Low

High

”

an

Rant in Orderut Dataset

Ranking IHre: NIEws

Enrichment plot: REACTOME_INNATE_IMMUNE_SYSTEM

Enrichment plot: REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTE

M

-

sn

0

Ranking nebic sopa

C

Wnt signaling pathway, planar cell polarity pathway

vascular endothellal growth factor receptor signaling pathway

T cell receptor signaling pathway

stimulatory C-type lectin receptor signaling pathway

-log:0(Qvalue)

-

20

protein polyubiquitination

16

40

NIK/NF-kappaB signaling

.

negative regulation of apoptotic process

Gene number

..

MAPK cascade

15

innate immune response

.

25

Fe-epsilon receptor signaling pathway

cell proliferation

antigen processing and presentation-

0.025

0.050

0.075

Rich factor