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Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess

Suppl. Table 1: Mitotane daily dose and plasma concentrations in the two Leydig cell tumor patients. Therapeutic range for plasma mitotane in adrenal cancer is accepted as 14-20 mg/L

	Patient 1		Patient 2
Duration of mitotane treatment (months)	Mitotane Dose (g/d)	Plasma Mitotane (mg/L)	Mitotane Dose (g/d)	Plasma Mitotane (mg/L)
1	1.5	4.0	4.5.	n.m.
2	3	5.9	4.5	9.1
4	3	9.1	4.5	14.2
5	3	23.5	4.5	n.m.
6	2	17.6
7	3	9.2

n.m., not measured.